王磊
师资介绍
王磊,男,汉族,1989年3月生,博士,讲师。
研究方向:
非天然核酸药物和小分子药物创制
基金项目:
1.江苏省“双创博士”项目
2.永利集团88304官网集团高层次人才项目
3.大学生创新创业计划项目(指导教师)
4.永利集团88304官网集团大型仪器开放基金
代表性论文:
1. The Development of Non-natural Type Nucleoside to Stabilize Triplex DNA Formation against CG and TA Inversion Site, Curr. Med. Chem., 2024,
2. Inhibition of transcription and antiproliferative effects in a cancer cell line using antigene oligonucleotides containing artificial nucleoside analogues, RSC Med. Chem., 2023, 14, 1482-1491.
3. Enhancement of the Utilization of Antigene Oligonucleotides in the Nucleus using Booster Oligonucleotides, Chem. Comm., 2020, 56 (67), 9731-9734.
4. Modification of the aminopyridine unit of 2'-deoxyaminopyridinyl-pseudocytidine allowing triplex formation at CG interruptions in homopurine sequences, Nucleic Acids Res., 2018, 46 (17), 8679-8688.
5. Effect of the 3-halo substitution of the 2’- deoxy aminopyridinyl-pseudocytidine derivatives on the selectivity and stability of antiparallel triplex DNA with a CG inversion site, Bioorg. Med. Chem., 2017, 25(14), 3853-3860.