刘兆国

作者:金飞     日期:2023-09-21   点击数:3086  

师资介绍

刘兆国,男,汉,198711月生,博士,副教授,硕士研究生导师

研究方向:

消化系统疾病(结肠癌、肝纤维化)的发病机理与中药复方及活性成分干预研究

主持科研项目:

1)国家自然科学基金委员会,面上项目,82374228,乌梅丸通过AHCY蛋白介导RIG-I乳酸化修饰调控巨噬细胞极化抗CAC的作用及机制研究,2024/01-2027/1249万元,在研,主持

2)国家自然科学基金委员会,青年基金,81703884,基于PKCδ介导的自噬调控探究黄葵胶囊对顺铂肾毒性的保护作用及分子机制,2018/01-2020/1220万元,已结题,主持

3)中国博士后科学基金会,面上项目,2018M642296,黄葵胶囊抗顺铂所致肾毒性的机理研究,2018/11-2020/085万元,已结题,主持

4)江苏省教育厅,高等学校(自然科学)研究面上项目,17KJB360012,黄葵胶囊对顺铂肾毒性的保护作用及机理研究,2017/09-2019/083万元,已结题,主持

5)南通市科技局,科技计划项目,JC2021025,基于 MIF/MIOX/铁死亡信号调控探究黄葵胶囊抗顺铂急性肾损伤的机制研究,2021/07-2023/065万元,已结题,主持

代表性论文:

1Zirong Deng#, Yun Xu#, Yuchen Cai, Weiling Lin, Libei Zhang, Aoqing Jiang, Yuhang Zhou, Rui Zhao, Heyan Zhao, Zhaoguo Liu*通讯作者 and Tingdong Yan*. Inhibition of ribosomal RNA Processing 15 homolog (RRP15) suppressed tumor growth, invasion and epithelial to mesen-chymal transition (EMT) of colon cancer [J]. International Journal of Molecular Sciences, 2023, 24(4): 3528.

2Libei Zhang#, Weiling Lin#,Yunqing Cai#, Ziyou Huang, Rui Zhao, Tingdong Yan, HongtaoXu*, Zhaoguo Liu*通讯作者. Farnesoid X receptor activation is required for the anti-inflammatory and anti-oxidative stress effects of Alisol B 23-acetate in carbon tetrachloride-induced liver fibrosis in mice [J]. International Immunopharmacology, 2023, 123:110768.

3Jue Wang#, Kang Ding#, Yuhang Wang#, Tingdong Yan, Yun Xu, Zirong Deng, Weiling Lin, Libei Zhang, Weizhong Zhu, Rui Zhao, Yuhang Zhou, Zhaoguo Liu*通讯作者. Wumei Pill ameliorates AOM/DSS-induced colitis-associated colon cancer through inhibition of inflammation and oxidative stress by regulating S-adenosylhomocysteine hydrolase- (AHCY-) mediated hedgehog signaling in mice [J]. Oxidative Medicine and Cellular Longevity, 2022, 2022:4061713.

4Zhaoguo Liu#第一作者, Mengjue Tu#, Jiannan Shi#, Hong Zhou, Guoliang Meng, Jianguo Gu*, Yuqin Wang*. Inhibition of fucosylation by 2-fluorofucose attenuated acetaminophen-induced liver injury via its anti-inflammation and anti-oxidative stress effects [J]. Frontiers in Pharmacology, 2022, 13:939317.

5Chang Chen#, Jingya Gu#, Jue Wang#, Yu Wu, Aihua yang, Tingting Chen, Tingting Zhou, Zhaoguo Liu*通讯作者. Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis throughinflammation inhibition by regulating SIRT3-mediated NF-κB P65nuclear expression [J] International Immunopharmacology, 2021, 90: 107206.

6Yuqin Wang#, Chunling Li#, Jingya Gu #, Chang Chen, Jiaxin Duanmu, Jing Miao, Wenjuan Yao, Jinhua Tao, Mengjue Tu, Biao Xiong, Lingling Zhao*, Zhaoguo Liu*通讯作者. Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signaling [J]. Journal of Cellular and Molecular Medicine, 2020, 24(1): 941-953.

7Jingya Gu#, Chang Chen#, Jue Wang#, Tingting Chen, Wenjuan Yao, Tingdong Yan*, Zhaoguo Liu*通讯作者. Withaferin A exerts preventive effect on liver fibrosis through oxidative stress inhibition in a sirtuin 3-dependent manner [J]. Oxidative Medicine and Cellular Longevity, 2020, 2020: 2452848.

8Jinlin Zhang, Aihua Yang, Yu Wu, Wei Guan, Biao Xiong, Xiaoqing Peng, Xiaojin Wei, Chang Chen, Zhaoguo Liu*通讯作者. Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats [J]. Biomedicine & Pharmacotherapy, 2018, 97:1586-1594.

9Zhaoguo Liu#,*通讯作者, Pingting Zhu#, Lin Zhang, Biao Xiong, Jinhua Tao, Wei Guan, Chunling Li, Chang Chen, Jingya Gu, Jiaxin Duanmu, Wei Zhang *. Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis [J]. Biomedicine & Pharmacotherapy, 2018, 103:1262-1271.

10Lin Zhang#, Chang Chen#, Jiaxin Duanmu, Yan Wu, Jinhua Tao, Aihua Yang, Xiaoqin Yin, Biao Xiong, Jingya Gu, Chunling Li, Zhaoguo Liu *通讯作者. Cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating MMP/TIMP system, PI3K/Akt/mTOR signaling and HIF-1α nuclear translocation [J]. International Immunopharmacology, 2018, 65: 429-437.

11Pingting Zhu#, Yu Wu#, Aihua Yang, Xingsheng Fu, Ming Mao, Zhaoguo Liu*通讯作者. Catalpol suppressed proliferation, growth and invasion of CT26 colon cancer by inhibiting inflammation and tumor angiogenesis [J]. Biomedicine & Pharmacotherapy, 2017, 95:68-76.

12Zhaoguo Liu#第一作者, Hongyan Wu#, Zhonghong Wei, Xu Wang, Peiliang Shen, Siliang Wang, Aiyun Wang, Wenxing Chen, Yin Lu*. TRPM8: a potential target for cancer treatment [J]. J Cancer Res Clin Oncol, 2016, 142(9):1871-1881.

社会学术兼职:

江苏省药理学会临床前药理专委会委员

江苏省双创人才(科技副总)

Frontiers in Bioscience-Landmark杂志编委

所获奖项及荣誉:

南通市首届十佳中药年度人物2022

永利集团88304官网集团第十二届青年教师讲课竞赛一等奖2021

永利集团88304官网集团优秀教育工作者2021

参编著作:

《血管生成研究方法与技术》(专著),人民卫生出版社,编委

授权发明专利:

刘兆国,杨圣菊,彭晓露,陈畅,顾静雅白桦醇及其衍生物在制备抗肿瘤药物中的应用,专利号:ZL201910201989.5